GLP-1 dose schedules

Every GLP-1 medication follows a step-up titration schedule designed to give your body time to adapt. Below are the reference ladders for the six FDA-approved drugs — each compiled from the official prescribing information.

Ozempic

Full guide →

semaglutide · Once weekly

Reference dose ladder · Once weekly

Initial (titration)

0.25 mg

4 weeks

Step 1

0.5 mg

4 weeks

Maintenance

1 mg

hold

Maximum

2 mg

hold

Educational reference only — your prescriber sets your actual schedule.

Wegovy

Full guide →

semaglutide · Once weekly

Reference dose ladder · Once weekly

Initiation

0.25 mg

4 weeks

Step 1

0.5 mg

4 weeks

Step 2

1 mg

4 weeks

Step 3

1.7 mg

4 weeks

Maintenance

2.4 mg

hold

Educational reference only — your prescriber sets your actual schedule.

Zepbound

Full guide →

tirzepatide · Once weekly

Reference dose ladder · Once weekly

Initiation

2.5 mg

4 weeks

Step 1

5 mg

4 weeks

Step 2

7.5 mg

4 weeks

Step 3

10 mg

4 weeks

Step 4

12.5 mg

4 weeks

Maximum

15 mg

hold

Educational reference only — your prescriber sets your actual schedule.

Mounjaro

Full guide →

tirzepatide · Once weekly

Reference dose ladder · Once weekly

Initiation

2.5 mg

4 weeks

Step 1

5 mg

4 weeks

Step 2

7.5 mg

4 weeks

Step 3

10 mg

4 weeks

Step 4

12.5 mg

4 weeks

Maximum

15 mg

hold

Educational reference only — your prescriber sets your actual schedule.

Saxenda

Full guide →

liraglutide · Once daily

Reference dose ladder · Once daily

Week 1

0.6 mg

1 weeks

Week 2

1.2 mg

1 weeks

Week 3

1.8 mg

1 weeks

Week 4

2.4 mg

1 weeks

Maintenance

3 mg

hold

Educational reference only — your prescriber sets your actual schedule.

Trulicity

Full guide →

dulaglutide · Once weekly

Reference dose ladder · Once weekly

Initial

0.75 mg

4 weeks

Step 1

1.5 mg

hold

Step 2

3 mg

hold

Maximum

4.5 mg

hold

Educational reference only — your prescriber sets your actual schedule.