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Glucagon

Glucagon is a hormone made in the pancreas. It does the opposite job to insulin: when blood sugar is low, it tells the liver to release stored sugar. Doctors sometimes call insulin and glucagon a balancing pair.

For experts

Glucagon is secreted by pancreatic alpha cells between meals and during fasting. It promotes hepatic glycogenolysis and, in prolonged fasting, hepatic and renal gluconeogenesis, opposing insulin action. GLP-1 receptor activation lowers glucagon secretion in a glucose-dependent manner, according to approved labelling for semaglutide.

Sources (3)

  1. 01Pancreatic regulation of glucose homeostasisExperimental & Molecular Medicine (PubMed Central, NCBI/NLM) · 2016-03-11 · accessed 2026-09-29
  2. 02OZEMPIC (semaglutide) injection, solution - FDA-approved prescribing informationU.S. National Library of Medicine, DailyMed · 2026-06-10 · accessed 2026-09-29
  3. 03Mechanisms of Action and Therapeutic Application of Glucagon-like Peptide-1Cell Metabolism (indexed in PubMed, NCBI/NLM) · 2018-04-03 · accessed 2026-09-29