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Amylin

Amylin is a hormone made by the same pancreas cells that make insulin. It helps control blood sugar after meals and helps you feel full. A drug based on amylin has been used for diabetes, and amylin-type drugs are being studied for weight loss.

For experts

Amylin is a 37-amino-acid peptide co-produced with insulin by pancreatic beta cells. Its receptors are G-protein-coupled receptors built from a core receptor protein plus receptor activity-modifying proteins (RAMPs), and it acts principally in circumventricular organs of the brain and interacts functionally with other metabolic hormones. The amylin analogue pramlintide is used clinically in type 1 and type 2 diabetes; the review notes clinical studies suggesting amylin agonists may aid weight loss, especially in combination with other agents.

Sources (2)

  1. 01Amylin: Pharmacology, Physiology, and Clinical PotentialPharmacological Reviews (indexed in PubMed, NCBI/NLM) · 2015-07 · accessed 2026-09-29
  2. 02Pancreatic regulation of glucose homeostasisExperimental & Molecular Medicine (PubMed Central, NCBI/NLM) · 2016-03-11 · accessed 2026-09-29